Protein Details: Two pore potassium channel protein sup-9

Protein ID

ICDB_Pro_0188

Protein Name

Two pore potassium channel protein sup-9

Gene Name

sup-9; F34D6.3

Organism

Caenorhabditis elegans

Length

329 amino acids

AlphaFoldDB

AF-O17185-F1-model_v4.pdb

Function

Potassium channel involved in coordination of muscle contraction

Sequence

MKRQNIRTLSLIVCTLTYLLVGAAVFDALETENEILQRKLVQRVREKLKTKYNMSNADYEILEATIVKSVPHKAGYQWKFSGAFYFATTVITTIGYGHSTPMTDAGKVFCMLYALAGIPLGLIMFQSIGERMNTFAAKLLRFIRRAAGKQPIVTSSDLIIFCTGWGGLLIFGGAFMFSSYENWTYFDAVYYCFVTLTTIGFGDYVALQKRGSLQTQPEYVFFSLVFILFGLTVISAAMNLLVLRFLTMNTEDERRDEQEAILAAQGLVRVGDPTADDDFGRLPLSDNVSLASCSCYQLPDEKLRHRHRKHTEPHGGPPTFSGMTTRPKY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Low levels along surface of body-wall muscle cells; in vulval and intestinal muscles and; more weakly; in anal depressor and sphincter muscles. Also expressed in a subset of head neurons. s

DOI ID

10.1523/jneurosci.23-27-09133.2003; 10.1126/science.282.5396.2012; 10.1016/s0306-4522(01)00079-3; 10.1371/journal.pgen.1004175

RefSeq

NP_494333.1